The Significance of Differences in Melanocortin 3 Levels and their Relationship with Pulmonary Tuberculosis and Body Mass Index

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dc.contributor.authorAndi Tenriola
dc.contributor.authorNajdah Hidayah
dc.contributor.authorSubair Subair
dc.contributor.authorMuhammad Nasrum Massi
dc.contributor.authorIrda Handayani
dc.contributor.authorRosdiana Natzir
dc.contributor.authorIrawaty Djaharuddin
dc.contributor.authorHandayani Halik
dc.date.accessioned2024-01-09T15:02:25Z
dc.date.available2024-01-09T15:02:25Z
dc.date.issued2021-08-21
dc.description.abstractBACKGROUND: Melanocortin 3 Receptors (MC3R) levels plays a role in many biological systems, including energy homeostasis and regulation of fat metabolism. However, very few have researched the relationship between MC3R and tuberculosis (TB) and body mass index. AIM: This study explores the differences in serum MC3R levels in active TB, household contacts, and control groups, as well as at different body mass index status. This study tries to find out the relationship between MC3R and other variables. METHODS AND MATERIALS: Blood samples were taken from 53 active TB patients, 49 household contacts, and 30 healthy people as controls. The 132 samples were subjected to IGRA and ELISA examinations to determine differences in MC3R levels in all groups. RESULTS: The highest mean of MC3R levels were found in the active TB group at 1.259.55 (p = 0.028) and had a positive correlation with a value of p = 0.008. In the sex group, men had the highest levels (p = 0.551). In the 30–49 year age group, the median value increased significantly in the three groups (p = 0.028), and there was a correlation between MC3R and the 17–29 year age group, although the correlation was negative (p = 0.021), in the 30–49 year age group with a positive correlation (p = 0.050). The mean MC3R value increased significantly in the overweight group in the three groups (p = 0.006) but did not significantly correlate. CONCLUSION: The high level of MC3R in TB patients is related to its role as a defence against microbes that enter the body through the immune process to prevent further infection and inflammation. Meanwhile, high levels of MC3R in excess Body mass index were associated with the function of MC3R as an inhibitor of pro-opiomelanocortin (POMC) neurons to release α-MSH.
dc.identifier.citationTenriola, A., Hidayah, N., Subair, S., Massi, M. N., Handayani, I., Natzir, R., ... & Halik, H. (2021). The The Significance of Differences in Melanocortin 3 Levels and their Relationship with Pulmonary Tuberculosis and Body Mass Index. Open Access Macedonian Journal of Medical Sciences (OAMJMS), 9(A), 583-588.
dc.identifier.issn1857-9655
dc.identifier.urihttps://repository.unimerz.ac.id/handle/123456789/234
dc.language.isoen
dc.publisherScientific Foundation SPIROSKI, Skopje, Republic of Macedonia
dc.titleThe Significance of Differences in Melanocortin 3 Levels and their Relationship with Pulmonary Tuberculosis and Body Mass Index
dc.typeArticle
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