Browsing by Author "Ahyar Ahmad"
Now showing 1 - 3 of 3
Results Per Page
Sort Options
- ItemAssociation of Vitamin D Receptor Polymorphism (rs2228570, rs1544410, rs7975232, and rs731236) and Macrophage Migration Inhibitory Factor -173 G/C (rs755622) with the Susceptibility of Active Pulmonary Tuberculosis in Makassar, Indonesia(Scientific Foundation SPIROSKI, Skopje, Republic of Macedonia, 2021-10-16) Najdah Hidayah; Irawaty Djaharuddin; Ahyar Ahmad; Rosdiana Natzir; Ilhamjaya Patellongi; Agussalim Bukhari; Irda Handayan; Andi Tenriola; Subair Subair; Handayani Halik; Muhammad Nasrum MassiBACKGROUND: The study of Vitamin D Receptor (VDR) and Macrophage Migration Inhibitory Factor (MIF) polymorphisms associated with active pulmonary tuberculosis (TB) (ATB) presents varying results. AIM: This study aimed to investigate the association between VDR rs2228570, rs1544410, rs7975232, and rs731236 and MIF -173 G/C (rs755622) single-nucleotide polymorphism (SNP), with susceptibility of developing ATB, and positivity of interferon-gamma release assay (IGRA) results (in household contact). MATERIALS AND METHODS: This study involved 83 ATB and 73 household contacts in Makassar. We checked IGRA based on ELISA in household contacts by using QuantiFERON-TB Gold Plus test, and we found that 61.64% (n = 45) of household contacts had positive IGRA. Polymorphism examination was carried out by Sanger sequencing. RESULTS: VDR rs2228570 T/T and T/C-T/T were significantly associated with a higher risk of active TB. VDR rs7975232 G/G genotype was associated with an increased risk of developing active TB compared to T/T-T/G. Haplotype analysis of VDR rs2228570, rs1544410, rs7975232, and rs731236 and combination with MIF rs755622 demonstrated that TGGTG was observed to have a higher risk of TB. CONCLUSIONS: The combination of VDR and MIF variants may contribute to the susceptibility of active tuberculosis disease.
- ItemSynthesis and interaction of adenosine-5'-triphosphate with rare earth metal Europium (Eu3+)(American Institute of Physics, 2020-11-06) Santi; Abdul Wahid Wahab; Indah Raya; Ahyar AhmadLanthanides and nucleotides can from attractive organic coordiantion polymers. Our study explore about the reaction of adenosine-5- triphoshate (ATP) with europium and study its bonding characteristic through the FT_IR Spectrum and UV-Vis spectoscopy. The Result Showed that the Eu (III) complex with adenosine-5-triphosphate (ATP) was successfully synthesized and could interact in oxygen atoms from the phospate group and nitrogen atoms from the ademine base with the highest absorption at the ATP.
- ItemSynthesis, spectroscopic (FT-IR, UV–visible) study, and HOMO-LUMO analysis of adenosine triphosphate (ATP) doped trivalent terbium(Elsevier, 2021-08-05) Santi Santi; Abdul Wahid Wahab; Indah Raya; Ahyar Ahmad; Maming MamingThe lanthanides and nucleotides can form attractive organic coordination polymers. The ligand complex adenosine-5 -triphosphate (ATP) with metal Terbium (Tb 3 + ) has been successfully synthesized. The com- plexes were characterized by FT-IR spectroscopy and UV–vis spectroscopy. The results showed that the metal Tb(III) coordinates with adenosine-5 -triphosphate (ATP) through the electrons in the oxygen atom from the phosphate group and the electrons on the nitrogen atom in the adenine ring. FT-IR proved the existence of ATP-Tb with a vibration band of 908 cm −1 and 349 cm −1 to form a P-O-Tb bond and a vi- bration band of 1635 cm −1 showing the coordination of Nitrogen N1 and N7 atoms as electron donors in terbium metal. The absorption bands at λ= 318.5 nm and 485.5 nm represent the electronic transi- tions of 7 F 6 → 5 H 7 and 7 F 5 → 5 D 4 and the redshift occurs after the addition of Tb 3 + to ATP with the mole ratio of ATP: Tb [1: 2]. The direct band gap obtained from 4.19 to 4.7 eV as a wide band gap semi- conductor material and the indirect band gap obtained from the 5.5–6.0 eV range is an insulator. The HOMO-LUMO energy band gap of the ATP-Tb complex is 3.721 eV. This value is similar to that obtained from experiments using the UV–visible spectrum. Calculations of band gap energies, interactions, and spectral properties of complex compounds can provide the basis for the design of wide band gap semi- conductor materials for rare earth complexes with organic ligands. The electronic properties of ATP-Tb have been calculated Ionization potential (I), electron affinity (A), chemical hardness ( η), chemical soft- ness ( ζ), chemical potential ( μ), electronegativity ( Х ), dan electrophilicity index ( ω).